I'm using Xamarin Studio Version 5.5 (build 227).
I have recently installed it on a new machine along with the Android SDKs (23.0.5).
First problem is that whenever I opt to edit a .XAML file I get the error message that the layout renderer has disconnected. But this is not the main problem as I normally prefer to edit the "xml" manually.
The main problem is that if I edit the resource layout I cannot then save the changes unless I quit Xamarin Studio. Using File menu to save the file errors, closing the file - which prompts a save) errors and opting to do a build goes into an endless loop (presumably trying and failing to save the changes).
This is frustrating as I'm in a "make the UI a bit better" phase of development.