I'm unable to connect to any of my devices anymore. I can connect to my 5.1.1 iPod, the app runs, I can see messages in the console, but the "Connecting to Debugger" message never goes away, and eventually says "Could not connect to the Debugger".
I upgraded Monotouch/Monodevelop to no avail. Version info below. I did download the 6.1 beta on my ipad, and on that one, I get the same message but the app does not start. For the current test with 5.1.1, I'm using xcode 4.52 as you can see below. The xcode 4.6 is in a beta directory, so it's not being used for general development.
The problem did exist under 6.0.4 as well. I upgraded Monotouch to see if the error would go away.
MonoDevelop 3.0.5 Runtime: Mono 2.10.9 (tarball) GTK 2.24.10 GTK# (184.108.40.206) Package version: 210090011 Apple Developer Tools: Xcode 4.5.2 (1847) Build 4G2008a Monotouch: 6.0.6